Yamazaki joined the
National Space Development Agency of Japan (NASDA) in 1996 and was part of the development team for the system integration of the
Japanese Experiment Module (JEM). She also worked on the JEM failure analysis and creating initial operation procedures. From June 1998 to March 2000, she was part of the ISS Centrifuge team (life science experiment facility) conducting conceptual framework and preliminary design. Since 2001, Yamazaki has participated in ISS Advanced Training and supported the development of the hardware and operation of the
Japanese Experiment Module. In November 2008, JAXA announced that Yamazaki would become the second Japanese woman to fly in space on
STS-131, which launched on 5 April 2010. Since the
Space Shuttle retired the following year in 2011, she was also the last Japanese astronaut to fly the Space Shuttle. On April 5, 2010, Yamazaki entered space on the shuttle
Discovery as part of mission STS-131. She returned to Earth on April 20, 2010. and
Expedition 23 (Yamazaki on the top right), the first time four women being at the same time in space. Yamazaki retired from JAXA on August 31, 2011. ==Post JAXA==