It is estimated that the plague may have claimed up to 1,250,000 lives throughout the Kingdom of Naples, making it
one of the deadliest epidemics in history. In
Barletta, 7,000–12,000 people died, out of the original 20,000 population. Outside the Kingdom of Naples, in Rome (capital of the
Papal State), around 23,000 people (or 19% of the local population) perished. In
Genoa, approximately 60,000 people died due to the epidemic, accounting for 60% of the local population. Outside of Italy, Spain suffered about 1,250,000 losses or about 19% of their population (this includes deaths from the 1599 outbreak). == Economic impact ==