Main •
Pedro Pascal as
Javier Peña, DEA agent tasked with taking down the Cali cartel •
Damián Alcázar as
Gilberto Rodríguez Orejuela – the leader of the
Cali Cartel and one of Pablo Escobar's primary rivals •
Alberto Ammann as
Hélmer "Pacho" Herrera – a Colombian drug lord and high-ranking member of the
Cali Cartel •
Francisco Denis as
Miguel Rodríguez Orejuela – a high-ranking member of the Cali Cartel and Gilberto's younger brother • Pêpê Rapazote as
José "Chepe" Santacruz-Londoño – a high-ranking member of the Cali Cartel who oversees the group's operations in New York City •
Matias Varela as
Jorge Salcedo Cabrera – the Cali Cartel's head of security •
Javier Cámara as
Guillermo Pallomari – the chief accountant of the Cali Cartel •
Arturo Castro as David Rodríguez – Miguel's son •
Eric Lange as Bill Stechner – the CIA Station Chief in Colombia •
Andrea Londo as María Salazar – wife of Claudio Salazar, a Colombian drug lord affiliated with the
North Valley cartel •
Kerry Bishé as Christina Jurado – the American wife of a banker affiliated with the Cali cartel •
Michael Stahl-David as Chris Feistl – DEA agent working under Peña •
Matt Whelan as Daniel Van Ness – DEA agent partnered with Feistl •
José María Yazpik as
Amado Carrillo Fuentes - a Mexican drug trafficker allied with Pacho and the Cali cartel, known as "The Lord of the Skies" • Juan Carlos Messier as Gustavo Calderón, a corrupt police captain who is murdered by the Cali cartel
Recurring •
Juan Sebastián Calero as Navegante, a violent associate of the Cali Cartel who works as their top henchman •
Juan Pablo Shuk as Colonel
Hugo Martínez, the commander of
Search Bloc •
Brett Cullen as Ambassador Arthur Crosby, a former Navy officer sent as US Ambassador to Colombia by
George H. W. Bush in 1992, replacing Noonan • Gaston Velandia as
José Serrano, General of the Colombian National Police •
Margarita Rosa de Francisco as Carolina Álvarez, Colombian journalist working for
El Tiempo • Roberto Cano as Darío, David Rodriguez's partner in crime •
Sebastián Eslava as Nicolas Rodrígue, Gilberto's son •
Miguel Ángel Silvestre as Franklin Jurado •
Edward James Olmos as Chucho Peña, Javier's father •
Raymond Ablack as Stoddard •
Shea Whigham as Agent Duffy •
Gabriel Iglesias as Dominican Gangster •
Carlos Camacho as Claudio Salazar •
Taliana Vargas as Paola Salcedo •
Bre Blair as Lorraine •
Wayne Knight as Alan Starkman •
Andrés Crespo as Carlos Córdova •
Lux Pascal (under Lucas Pascal) as Elias ==Episodes==