College in United States Opoku played for
Lindsey Wilson College in
Columbia, Kentucky, where he scored 19 goals and five assists in 19 games in 2021. In 2022, Opoku transferred to
Syracuse University, where he became a prominent striker in the
Atlantic Coast Conference under head coach
Ian McIntyre. He totaled 11 goals and eight assists in 25 matches for Syracuse. At the end of the 2022 season, Opoku was named to
United Soccer Coaches’ Third-Team All-America and
All-ACC First Team as well as he was the
NCAA College Cup Most Outstanding Offensive Player, 2022 NCAA All-Tournament Team honoree.
Ventura County Fusion Opoku played for
Ventura County Fusion in
USL League Two in 2022. He played and was named as the MVP as Fusion defeated the
Long Island Rough Riders to win the USL League Two championship in 2022. Opoku scored 11 goals in 16 appearances in 2022 for Ventura County Fusion.
Leicester City In January 2023, Opoku was reported to have signed for Premier League club
Leicester City and loaned to Belgian club
OH Leuven. According to Sky Sports News, Opoku rejected the opportunity to be a top pick in the
2023 MLS SuperDraft in favour of the European move. Opoku scored his first league goal for Leuven on April 8, 2023, in a 4–1 home win against
KV Mechelen. In April 2024, he suffered a double leg fracture playing for Leuven against
Westerlo. On 1 September 2025, Opoku joined
EFL League Two club
Newport County on loan until January 2026. He scored his first goal for Newport on his debut five days later, coming on as a substitute for
Matt Baker in the 64th minute of a 3–2 home defeat to
Bristol Rovers in the league. On 1 January 2026, his loan was extended until the end of the 2025-26 season. ==Personal life==