Detective Nathan West arrives in Port Charles, and meets
Maxie Jones (
Kirsten Storms) when he sublets her apartment. Maxie leaves on a vacation, while Nathan settles in Port Charles. He starts investigating
Dr. Silas Clay (
Michael Easton) in regards to the overdose of Silas' wife,
Nina Reeves (
Michelle Stafford), suspecting Silas is responsible. It's later revealed Nathan is actually Nina's brother. Nathan's mother
Madeline Reeves (
Donna Mills) claims Nina has died after Silas has relinquished his rights to Nina's vast estate. Nathan is shocked when Madeline falls into the trap to catch the killer, and confesses she drugged Nina to kill her unborn child. He arrests Madeline, and simultaneously reveals his identity. Maxie returns with her new manipulative boyfriend
Levi Dunkleman (
Zachary Garred), who Nathan immediately clashes with. Nathan meets
Britt Westbourne (
Kelly Thiebaud) at the same time it's revealed Nathan is the biological son of
Liesl Obrecht (
Kathleen Gati), Madeline's sister, and Britt is actually his sister. Madeline confesses to Nathan when he mentions almost sleeping with Britt. Nathan is shocked when Madeline reveals Nina is alive as she is carted off to prison. Maxie is trying to regain custody of her daughter
Georgie, but is discouraged about going to her hearing. Nathan encourages Maxie to fight for Georgie, then covers for her, lying he threw her summons away by mistake. When the judge discovers Nathan lied for Maxie and she loses custody of her daughter, Nathan suspects Levi tipped off the judge, and tries to prove it. Meanwhile, Nathan is reunited with Nina, who arrives in Port Charles. Levi later frames Nathan for tipping off immigration about Levi's expired visa, leading to Maxie throwing Nathan out of the apartment. As Maxie is set to marry Levi, Nathan discovers Levi has stolen a family heirloom from Maxie's mother
Felicia Scorpio (
Kristina Wagner). With the help of his partner
Dante Falconeri (
Dominic Zamprogna), Nathan crashes the wedding, only for Levi to escape with Maxie and Dante's wife,
Lulu (
Emme Rylan), at gunpoint. Nathan tracks down Maxie, but is kidnapped by
Victor Cassadine (
Thaao Penghlis). Nathan is about to kill Victor until Obrecht says they are father and son. Nathan rescues Maxie, and the two end up killing Levi and his father,
Peter Harrell (
David Gautreaux). As they escape, it was revealed Victor isn't Nathan's father. Obrecht kills Victor to keep Nathan from finding out. Nathan and Maxie start dating, but when Maxie is threatened with losing custody of Georgie again, they're forced to stay apart. Nathan asks for help from his mother, who arranges for
Monica Quartermaine (
Leslie Charleson) to appeal to the judge on Maxie's behalf. A thrilled Maxie gets visitation rights to Georgie, and she and Nathan finally start a relationship freely. Nathan moves out at Maxie's request they ease into their relationship. They later clash when Maxie helps fugitive
Johnny Zacchara (
Brandon Barash) skip town. Georgie returns with her father
Damian Spinelli (
Bradford Anderson), who is hoping to reunite with Maxie. Maxie dumps Nathan after she blames him for accepting Spinelli's challenge to box for her affections. Nathan teams up with Spinelli's ex-girlfriend
Ellie Trout (
Emily Wilson), pretending to date to make their respective lovers jealous. The plan works, and Maxie and Nathan reunite after the Nurses' Ball. Silas is found dead, and Nina is accused of murdering him. Wanting to prove Nina innocent, Nathan investigates, and starts to suspect
Ric Lansing (
Rick Hearst), Nina's new husband whom she randomly married. Nathan figures out Ric married Nina on Madeline's request, to drive Nina crazy and gain Nina's inheritance. Nathan gets Ric's cooperation, and is able to arrest Madeline for Silas' murder, disgusted by her actions. When Nathan is shot in 2016, under the influence of drugs, he refers to Maxie as "Claudette." Maxie later asked Nathan who Claudette is, and he claims it was his dog. Nathan later admits she's his ex-wife,
Claudette Beaulieu. Nathan admits he and Claudette had a green card marriage, but he fell in love with her till he discovered she was cheating on him. Nathan later confesses to Obrecht he didn't tell Maxie the entire story. After he and Maxie get engaged, Nathan admits he discovered Claudette's infidelity when he walked in on her and her lover. Drunk and angry, he shot Claudette's lover, who disappeared. Maxie is hesitant to trust Nathan, but they soon reconcile, only for Claudette (
Bree Williamson) to show up in town. Maxie convinces Nathan to let Claudette stay to keep an eye on her. Nathan discovers his recent confidant
Griffin Munro (
Matt Cohen) was Claudette's lover. Furious, he attacks Griffin. Maxie and Claudette have to pull him off. Maxie accuses him of still being in love with Claudette, but he convinces her this is not true, and he loves her. Claudette asks Nathan for help to protect her daughter,
Charlotte (Scarlett Fernandez) – who she claims is also Nathan's daughter – from Claudette's ex-lover,
Valentin Cassadine (
James Patrick Stuart). Rightfully suspicious, Maxie exposes Charlotte is not Nathan's daughter. Claudette eventually skips town, and Nathan and Maxie get back to planning their wedding. They're set to marry on New Year's Eve, but Nathan finds out his marriage to Claudette was never annulled, hence they're still married and he can't marry Maxie. He and Maxie fly to Canada to track down Claudette, and find out she's dead. Nathan and Maxie return, and finally get married in early 2017. When Maxie goes to Portland for work, Nathan is left to wonder if the marriage can survive the long distance. Nathan learns Nurse
Amy Driscoll (Risa Dorken) has been writing the "Ask Man Landers" advice blog, using his picture. Nathan is initially upset until Amy reveals she is writing the column to support her brother Chet (Chris Van Etten), a war veteran who was wounded in action. When Amy lands a book deal, he agrees to help her out so she can pay Chet's medical bills. Maxie returns, and aims to expose Ask Man Landers' identity forcing Nathan to lie. Amy gives Nathan her blessing to tell Maxie the truth just as Maxie begins to suspect they are having an affair. Nathan and Amy's secret is exposed in tabloids forcing them to do damage control. Chet steps in and tells his story, winning sympathy and keeping Nathan and Amy from being charged with fraud. On Thanksgiving, Nathan is thrilled when Maxie reveals she's pregnant. In preparation for the baby's arrival, Nathan requests Victor's medical records. While Obrecht obtains the records, Nathan and Maxie realize the medical records are inconsistent with the
Cassadine family's genetic history and a DNA test later confirms Nathan is not a Cassadine after all. Obrecht is forced to admit that
Cesar Faison (
Anders Hove) is Nathan's biological father. Lulu convinces Nathan to do an exposé on him as Faison's son to help the authorities lure him out of hiding. Maxie fears the danger Faison could bring to their doorstep, but Nathan is determined to bring his father to justice. As expected, Faison shows up and takes Maxie and her boss
Peter August (
Wes Ramsey) hostage. Nathan comes to Maxie's rescue only to be shot by Faison. While he survives emergency surgery, Nathan dies in recovery shortly after professing his love for Maxie. He was buried with full policeman honors. Maxie later gives birth to a baby boy; in memory of Nathan, she names their son
James, Nathan's given name. In September 2025, Nathan's twin brother,
Cassius Faison, assumes Nathan's identity after a car crash, leading people to mistakenly believe he is Nathan due to their resemblance. ==Reception==