•
Simon Lipkin as Jerry Poppy, the younger brother of Desmond Poppy, the previous teaching assistant from the last three Nativity films. •
Craig Revel Horwood as Emmanuel Cavendish, rock legend and Jerry's childhood bully. •
Daniel Boys as Mr. Ben Johnson, the fourth school teacher of St. Bernadette's since
Martin Freeman as Mr. Paul Maddens in the first Nativity film,
David Tennant as Mr. Donald Peterson in
Nativity 2: Danger in the Manger and
Martin Clunes as Mr. Jeremy Shepperd in
Nativity 3: Dude, Where's My Donkey?. • Brian Bartle as Doru, a lost child. •
Ramin Karimloo as Doru's Dad •
Helen George as Miss Suzie Shelly, Doru's social worker and Mr. Johnson's new love interest. •
Celia Imrie as Mrs. Keen, the current headmistress of St. Bernadette's. Imrie returns from
Nativity 3: Dude, Where's My Donkey?. • Jalisa Andrews as Miss Lisa Bailey, the assistant to Mrs. Keen replacing
Rosie Cavaliero as Miss Lucy Rye, Mrs. Bevan's assistant who appeared in the first Nativity film and
Nativity 2: Danger in the Manger. • Gabriel Vick as Hugo Alexander, the new teacher at Oakmoor School replacing
Jason Watkins as Gordon Shakespeare, the previous teacher from the last three Nativity films. • Rupert Turnbull as Barnaby Hargreaves, a student at Oakmoor School and Doru's new friend. •
Anna Chancellor as Clara Hargreaves, Barnaby's mum. •
Hugh Dennis as Robert Hargreaves, Barnaby's dad. •
Ruth Jones as Farmer Beatie, a farmer who helps Doru and his dad find each other. • Jamie Chapman as Tony, Cavendish's manager. •
Vincent Franklin as Lord Mayor, the mayor of Coventry replacing
Ricky Tomlinson as the previous mayor from the first Nativity film. •
Meera Syal as Nina, a foster carer of Doru and a friend of Miss Shelly. •
Jessica Hynes as Angel Matthews, the singer of the rock opera. Hynes returns from
Nativity 2: Danger in the Manger. ==Reception==