Talpur was elected to the
National Assembly of Pakistan as a candidate of
Pakistan People's Party (PPP) from NA-175 Mirpurkhas-cum-Umerkot in the
1993 Pakistani general election. He received 40,780 votes and defeated
Pir Noor Muhammad Shah Jeelani, a candidate of
Pakistan Muslim League (N) (PML-N). He contested the
1997 Pakistani general election as a candidate of PPP from NA-175 Mirpurkhas-cum-Umerkot, but was unsuccessful. He received 22,310 votes and was defeated by Pir Noor Muhammad Shah Jeelani, a candidate of PML-N. He was re-elected to the National Assembly as a candidate of PPP from
NA-228 (Mirpurkhas-III) in the
2002 Pakistani general election. He received 58,161 votes and defeated
Kishan Chand Parwani, a candidate of the
National Alliance (NA). He was re-elected to the National Assembly as a candidate of PPP from NA-228 (Umerkot) in the
2008 Pakistani general election. He received 75,080 votes and defeated an independent candidate,
Muhammad Qasim Soomro. Yousuf was re-elected to the National Assembly as a candidate of PPP from NA-228 (Umerkot) in the
2013 Pakistani general election. He received 99,700 votes and defeated
Shah Mehmood Qureshi, a candidate of
Pakistan Tehreek-e-Insaf (PTI). He was re-elected to the National Assembly as a candidate of PPP from
NA-220 (Umerkot) in the
2018 Pakistani general election and defeated Shah Mehmood Qureshi of PTI. He was re-elected to the National Assembly as a candidate of PPP from
NA-213 Umerkot in the
2024 Pakistani general election. He received 179,188 votes and defeated Mir Amanullah Khan Talpur, a candidate of
Pakistan Muslim League (N). == Death ==