Nebraska Highway 23 begins at the Colorado border at Venango. It passes northeasterly through farmland towards
Grant, where it meets
Nebraska Highway 61. After a brief concurrency, NE 23 and NE 61 separate and NE 23 continues east. Near
Wallace, NE 23 meets
Nebraska Highway 25. It continues east and near
Wellfleet, meets
U.S. Route 83. NE 23 turns south with US 83 and continues south until near
Maywood, where they separate. After going east through Maywood, NE 23 continues east and meets
Nebraska Highway 18 at
Curtis. After a brief segment which runs northward, it passes
Moorefield and continues on through
Farnam. Near Farnam, NE 23 meets
Nebraska Highway 47 and turns southeasterly. It passes through
Eustis and meets
Nebraska Highway 21. It continues southeasterly and meets
U.S. Highway 283 in
Elwood. It continues in a southeastern direction through
Smithfield,
Bertrand, and
Loomis and ends at an intersection with
US Routes 6 and
34 at the western end of
Holdrege. ==Major intersections==