Nebraska Highway 41 begins in
Clay Center at an intersection with
Nebraska Highway 14 and
Nebraska Spur 18D. It goes east out of Clay Center into farmland until
Geneva. In Geneva, it runs on an old alignment of
U.S. Highway 81. It meets US 81 just east of Geneva and continues east until meeting
Nebraska Highway 15. The two highways overlap for . It turns east and at
Wilber, meets
Nebraska Highway 103. It continues east through
Clatonia and briefly overlaps
U.S. Highway 77. It continues east and meets
Nebraska Highway 43 at
Adams. Highway 41 continues east until
Sterling, where it then angles southeasterly until
St. Mary. After St. Mary, the highway turns straight east again and ends at
Nebraska Highway 50 north of
Tecumseh. ==Major intersections==