NE-44 begins at an intersection with NE-4 south of Wilcox. It heads through farmland and passes through Wilcox, then meets
U.S. Route 6/
U.S. Route 6 (US 6/US 34), which are concurrent with each other. NE-44 then turns east with US 6/US 34 and passes through
Axtell. East of Axtell, NE-44 turns north. Near
Kearney, NE-44 meets
Nebraska Link 50A, which serves as a link to
Fort Kearny State Historical Park. Shortly after, NE-44 crosses the
Platte River and becomes a divided highway. NE-44 then enters Kearney and meets
Interstate 80, where it ends on the north side of the westbound I-80 ramps. The roadway continues north towards downtown Kearney as Second Avenue. ==Major intersections==