Nebraska Highway 91 begins at an intersection with
NE 2 just north of
Dunning. It heads in a northeasterly direction through the
Sand Hills, where it has an intersection with
NE 7 south of
Brewster. The highway continues to the east and southeast into farmland, heading into
Taylor. In Taylor, NE 91 meets
US 183 and runs concurrently southward with it for about a mile. NE 91 then splits off and head eastward, where it intersects with
NE 11 south of
Burwell. NE 91 and NE 11 run concurrently northward for a couple of miles as it passes through Burwell, before splitting off to head east again. West of
Ericson, the highway intersects
NE 70, where it then runs concurrently with that route for about . Further east, NE 91/NE 70 intersect with
US 281, which is where the overlap with NE 70 ends. NE 91 then runs concurrently southward. NE 91 then splits off and head eastward some more, passing through
Spalding. After leaving Spalding, the highway passes
NE 52. To the east, it enters
Albion where it intersects with
NE 14. Further east, it passes
NE 45 before entering
Lindsay. NE 91 intersects
US 81 northeast of
Humphrey. The highway continues to the east, where it passes
NE 57 north of
Leigh, as well as
NE 15 southeast of
Clarkson. In
Snyder, NE 91 passes by
NE 79 before continuing eastward. East of Snyder, it meets and runs concurrently southeastward with
US 275. After passing through
Scribner and bypassing
Hooper, NE 91/US 275 meet with
US 77 and run concurrently southward along it as well. North of
Fremont, NE 91 splits off to the east yet again. It continues eastward through
Nickerson and continues into
Blair, where it terminates at an intersection with
US 30 and
US 75. ==Major intersections==