Main •
Callie Thorne as Dr. Danielle "Dani" Santino (née Romano): The protagonist. Dr. Dani Santino is a tough divorcée who, to make ends meet, becomes the therapist for a professional football team and quickly becomes sought after by other athletes, musicians, politicians and those living in the spotlight. Starting season three she works for V3, a major talent agency in NYC, after being fired by the new GM/head coach of the New York Hawks. •
Marc Blucas as Matthew "Matt" Donnally (seasons 1–2): The New York Hawks' athletic trainer, and later general manager, to whom Dani was attracted. •
Scott Cohen as Dominic Eugene "Nico" Careles: A former
Navy SEAL from
Pittsburgh, head of security and "fixer" for first the Hawks and then V3. •
Hannah Marks as Lindsay Santino (seasons 1–2, guest season 3): Dani's rebellious teenage daughter. •
Patrick Johnson as Ray "Ray Jay" Santino Jr. (seasons 1–2): Dani's teenage son who is an avid fan of T.K., often using him to get things from the Hawks' team that regular fans could not. •
Mehcad Brooks as Terrence "T.K." King: The New Jersey Bobcats' star player, formerly the New York Hawks' star player and Dani's main focus when she was originally hired by the NY Hawks football team. • Karissa Lee Staples as Paloma Madsen (season 3): Dani's ambitious new assistant. •
John Stamos as Connor McClane (season 3): the founder of a sports and entertainment management empire named V3, who employs Dani.
Recurring •
Gregory Alan Williams as Coach Pat Purnell: The former head coach of the New York Hawks, now again TK's coach with the New Jersey Bobcats. •
Andrea Anders as Laura Radcliffe: A high-powered publicist hired by the Hawks to improve T.K.'s public image. She has also had a previous relationship with Matt Donnally. •
Amanda Detmer as Jeanette Fiero: Dani's best friend. •
Jason Gedrick as Dr. J. D. Aldridge: Dani's former grad school professor. •
Evan Handler as Marshall Pittman: Deceased former owner of the New York Hawks. •
Jaime Lee Kirchner as Vivica Stevens: A reporter who T.K. begins dating, but who later is dumped by T.K. after he is shot. •
Concetta Tomei as Angela: Dani's mother, and a gambler. •
Gaius Charles as Damon Razor/Bryce Abbot: An academic football player with a shady past who comes in as a runner-up for T.K. after he is shot. •
Rob Estes as Rob Maroney: T.K.'s agent who helped T.K. on his downward spiral after dealing with being shot. •
Michaela McManus as Noelle Saris: A reporter in behind Terrence King and Damon Razor, searching for Razor's past and threatening a sexual harassment suit on the team and T.K. •
Michael O'Neill as Hank Hooper: A friend of Coach Purnell, who was appointed by the league to be the Interim GM until the "Pittman situation" was resolved. •
Danielle Panabaker as Juliette Pittman: Daughter of Marshall Pittman, briefly owner of the Hawks. • Travis Smith as Rex Evans: A gay player for the Hawks and Dani's patient, who became friends with T.K. when the star quarterback helped him come out to the team and to the rest of the world. •
David Andrews as Coach Tom Wizinski: The new head coach and GM for the Hawks. •
David Anders as Troy Cutler: Connor's second-in-command at V3. •
Kate Miner as Sheera Kane, a top model who was dating T.K., looking to start a lingerie line with him, and was briefly engaged to him. • Nicholas X. Parsons as Stanzi Palmer, a computer hacker hired by V3 to assist Nico in collecting intelligence. •
Autumn Reeser as Abby Bruce, girlfriend of Connor. •
Mario Cimarro as Augusto, Spanish chef who returns incognito to help Dr. Dani surprise Jeanette. •
Ben Winchell as Eric ==Episodes==