In 1378, Nefise's brother
Bayezid married
Devletşah Sultan Hatun, princess of
Germiniyan. During the wedding reception, Nefise's father Murad I negotiated with the representatives of
Karaman, Ali Bey and Davud Bey, to give her in marriage to
Alaeddin Ali (ruler of Karaman, grandson of Ali and brother of Davud). Karaman was one of the most powerful
beyliks and, at the time, the main opponent of the Ottomans. The marriage was supposed to be the basis of an alliance between the two states, that were at that time adversaries. Nefise's dowry included 100,000 gold coins, one hundred horses, ten herds of camels, nine carpets, nine chests of jewels, gold, and precious stones, and more than fifty rolls of silk, velvet, and gold fabrics from France, Syria, Egypt, and Turkey. Her dowry in case of divorce consisted of the territories of
Aksehir and
Aksaray, including the neighboring villages and all income. At that point, the marriage was announced in both the states during
Friday prayers. The wedding ceremony was held in Bursa, with
Candarli Kara Halil as the bride's representative and Mevlana Muslihiddin as the groom's. Soon after, Nefise set out for
Karaman. During the journey, the procession was attacked by
Mongol raiders, who were, however, put to flight by the cavalry units escorting the princess. In Karaman, the wedding ceremony was repeated, this time in the presence of both bride and groom. Among the guests were the rulers of
Saruhan,
Aydin,
Menteşe and
Eshrefoglu. In Karaman, Nefise became known as Sultan Hatun (
Lady Sultana) in reference to her birth status. By their marriage was birth at least three children, three sons. ==Political activity ==