NELL2 has been implicated to be involved in a variety of different functions including neuronal development, sperm maturation, cancer progression and bone development.
NELL2 has been shown to have roles in neuronal polarization and axon growth.
NELL2 is a negative regulator of axon guidance in the
SLIT-ROBO signalling pathway where it binds with the ROBO3/Rig-1 receptor. It can also bind with ROBO2 under acidic conditions, where ROBO2 undergoes
proteolytic cleavage. ==References==