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NELL2

Protein kinase C-binding protein NELL2 is a secreted glycoprotein that in humans is encoded by the NELL2 gene. It is a homolog of Nel, which is a gene present in the neural tissues of chickens.

Function
NELL2 has been implicated to be involved in a variety of different functions including neuronal development, sperm maturation, cancer progression and bone development. NELL2 has been shown to have roles in neuronal polarization and axon growth. NELL2 is a negative regulator of axon guidance in the SLIT-ROBO signalling pathway where it binds with the ROBO3/Rig-1 receptor. It can also bind with ROBO2 under acidic conditions, where ROBO2 undergoes proteolytic cleavage. ==References==
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