In the early 1980s, Sewankambo was one of the earliest physicians in Uganda to recognize the new disease that caused patients to lose weight and "slim" down to abnormal
cachectic sizes. The new disease, at first called
Slim Disease, became known as
HIV/
AIDS. He has been at the forefront of research about the disease, specializing in HIV clinical drug trials. He has extensively published the finding of his research in
medical journals and other peer publications. In the late 1990s, he was appointed
Dean of
Makerere University School of Medicine. He served in that position until 2007 when he was promoted to the position of
Principal,
Makerere University College of Health Sciences, a position he still occupies. ==Other considerations==