Main •
Ryan Eggold as Dr. Maximus "Max" Goodwin,
MD, the
medical director at New Amsterdam Medical Center •
Freema Agyeman as Dr. Helen Sharpe, MD, Head of the
Oncology Department (seasons 1–4; guest season 5) •
Janet Montgomery as Dr. Lauren Bloom, MD, Head of the
Emergency Department •
Jocko Sims as Dr. Floyd Reynolds, MD, Head of the
Cardiothoracic Surgery Division •
Tyler Labine as Dr. Ignatius "Iggy" Frome, MD, Head of the
Psychiatry Department •
Anupam Kher as Dr. Vijay Kapoor, MD, former Head of the
Neurology Department (seasons 1–3) •
Sandra Mae Frank as Dr. Elizabeth Wilder, MD, a
deaf surgeon and the newest Chief of Oncology (season 5; recurring season 4)
Recurring • Michael Basile as Paramedic Robert Moreland • Megan Byrne as Gladys Miller, Dr. Frome's secretary • Christopher Cassarino as Dr. Edward Nottingham, a Senior Resident (later, Chief Resident) in Cardiothoracic Surgery • Christine Chang as Dr. Agnes Kao, a neurologist who is later promoted to succeed Dr. Kapoor as Head of Neurology •
Mike Doyle as Dr. Martin McIntyre, Dr. Frome's husband who works as an at-home
therapist • Em Grosland as Kai Brunstetter, an ED nurse •
Alejandro Hernandez as Casey Acosta, the Head Nurse of the ED • Matthew Jeffers as Dr. Mark Walsh, an ED Senior Resident who is later promoted to Chief Resident • Olivia Khoshatefeh as Dr. Yasmin Turan, an ED Resident • Keren Lugo as Dr. Diana Flores, an Attending Physician in Cardiothoracic Surgery •
Debra Monk as Karen Brantley, the chairwoman of New Amsterdam's Board of Directors • Teresa Patel as Paramedic Harvell • Stacey Raymond as Kerry Whitaker, a paramedic • Anna Suzuki as Sandra Fall, a billing associate •
Vandit Bhatt as Rohan, Dr. Kapoor's son (seasons 1–2, guest season 4) •
Margot Bingham as Evie Garrison, the associate director of the Legal Department (seasons 1–3) • Lizzy DeClement as Jemma, psychiatric patient (seasons 1–2) •
Michelle Federer as Millie Tamberlay (seasons 1–3) • Dierdre Friel as Ella, the mother of Dr. Kapoor's grandchild. She has
OCD. (seasons 1–3, guest season 4) •
Zabryna Guevara as Dr. Dora Williams, Dr. Goodwin's assistant (seasons 1–3) •
Nana Mensah as Dr. Camila Candelario (seasons 1–2) •
Lisa O'Hare as Georgia Goodwin, Dr. Goodwin's wife (seasons 1–2) •
Sendhil Ramamurthy as Dr. Akash Panthaki, an oncologist (season 1) • Emma Ramos as Mariana, an ED resident (seasons 1-3) •
Ron Rifkin as Dr. Peter Fulton, former dean of the hospital (seasons 1–2) •
Jennifer Betit Yen as Aimee Kamoe, an OR nurse (seasons 2–5) •
JJ Feild as Dr. Zach Ligon, a physical therapist (season 2) •
Gina Gershon as Jeanie Bloom (seasons 2–5) •
Daniel Dae Kim as Dr. Cassian Shin, a trauma surgeon (season 3, guest seasons 2 and 5) •
Alison Luff as Alice Healy (season 2) •
Ana Villafañe as Dr. Valentina Castro, the new co-head of the Oncology Department with Helen (season 2) • Nora and Opal Clow as Luna Goodwin, the daughter of Dr. Goodwin (season 3–5) • Shiva Kalaiselvan as Dr. Leyla Shinwari (seasons 3–5) • John McGinty as Dr. Liam Sertic (seasons 3–5) • Gemma McIlhenny as Maintenance Crew Janice (seasons 3–4) •
Frances Turner as Dr. Linda "Lyn" Malvo, the Head of the OB/GYN Department (seasons 3–5) •
Genevieve Angelson as Dr. Mia Castries, the newly appointed Head of the Holistic Medicine Department (seasons 4–5) •
Michelle Forbes as Dr. Veronica Fuentes, the "New" Medical Director (season 4) • Conner Marx as Ben Meyer, ASL interpreter who works with Dr. Elizabeth Wilder (seasons 4–5) • Jackie Roth as Dana Milliner, ASL teacher (season 5, episode 10)
Notable guest stars •
Frankie J. Alvarez as Carl Jiminez ("Croaklahoma", S1/E15) •
André De Shields as Dale Rustin ("The Legend of Howie Cournemeyer", S3/E7) •
Janet Hubert as Dr. Palpa ("Two Doors", S4/15) •
Bill Irwin as Calvin Bennett •
Peter Jacobson as Bob ("The Empty Spaces", S5/E9) •
Marlee Matlin as Dr. Bev Clemons ("Don't Do This For Me", S5/E10) •
Frankie Muniz as Jace ("Truth Be Told", S4/19) •
Mercedes Ruehl as Grace ("TBD", S5/E1) • John Douglas as Pizza Guy ("A Seat At The Table", S1/E11) ==Episodes==