SR 406 begins at an intersection with
US 56,
US 64, and
US 412 in a concurrency. The road then heads north, passing a few farms. At an intersection with County Route A055, the route turns right toward the Oklahoma border. The road zigzags northward and eastward again to an intersection with
SR 410, which heads east toward
Wheeless, Oklahoma. At SR 410, SR 406 again turns back north and hugs the Oklahoma border. The road then winds slightly passing through mountainous terrain. It terminates at
SR 456, which heads east as
Oklahoma State Highway 325 toward
Kenton. == Major intersections ==