Families living in the hamlet of
Cold Spring were brought in through the
Cornplanter Grant in the early 1800s, and by 1809, the village located along future–NY 280 exceeded 500 people in log houses. The alignment of future NY 280 appears in the 1869 Cattaraugus County Atlas on its alignment from Cold Spring to
Quaker Bridge. At the time a dirt road, a total of 14 families lived along the road. Construction of the Seneca Trading Post, a general store, began in 1833, which was a hub of activity at the southern end of the road in Quaker Bridge, supplying stuff for tourists of the area and serving as the town's post office until 1964. The building was intentionally burned in 1965. NY 280 was assigned as part of the
1930 renumbering of state highways in New York to a short roadway connecting
NY 17, then an at-grade highway, to the now-submerged
hamlets of Cold Spring and Quaker Bridge along the western bank of the
Allegheny River. The designation ended in Quaker Bridge, a community situated on the eastern riverbank near the modern junction of NY 280 and
Allegany State Park Route 3 in the town of
Elko. NY 280 remained relatively unchanged up through the early 1960s. In October 1960, ground was broken on the
Kinzua Dam, which would dam the Allegheny River downriver from NY 280 at a point east of
Warren, Pennsylvania. The structure was completed on December 13, 1965, leading to the creation of the
Allegheny Reservoir. Much of NY 280 was inundated by the new reservoir, as were Cold Spring, Quaker Bridge, and a significant portion of
Pennsylvania Route 346 (PA 346) that ran along the river in
Warren County. As a result, new alignments were built for both NY 280 and PA 346 along the eastern edge of the new reservoir. Construction of NY 280's new alignment began in 1965 and was completed by 1968. NY 280 now began at the realigned PA 346 at the state line and ended at exit 18 of the
Southern Tier Expressway, which was built between
Steamburg and
Salamanca during the mid-1960s. ==Major intersections==