NY 376 begins at an intersection with
NY 52 in the
hamlet of
East Fishkill. It proceeds north about , crossing over
Fishkill Creek and continuing into the hamlet of
Hopewell Junction, where it
overlaps with
NY 82 for . NY 376 leaves NY 82 and continues northwest, crossing railroad tracks and following a sharp 90° S-curve with a advisory speed. Soon after, the route traverses another curve, but at . After this, the speed limit returns to . NY 376 passes by the Dogwood Knolls Country Club before meeting
County Route 29 (CR 29) in the hamlet of
Fishkill Plains, at which point NY 376 proceeds west. Immediately after crossing from the town of
East Fishkill into the town of
Wappinger, NY 376 turns north at an intersection with
CR 93. It continues north for about through the hamlet of
Diddell, where it turns west again towards the hamlet of
New Hackensack. Here, the route meets
CR 94 and
CR 104. NY 376 turns north at this intersection, running along the eastern perimeter of and providing access to the passenger terminal of
Dutchess County Airport. North of the airport, NY 376 runs closely parallel to
Wappinger Creek, briefly entering the town limits of
La Grange before crossing the Wappinger Creek into the town of
Poughkeepsie. about from its junction with Cedar Avenue (known as
CR 74 south of the city limits). NY 376 follows Raymond Avenue for about a mile (1.6 km) to the hamlet of
Arlington. Here, it meets
US 44 and
NY 55, both of which follow a
one-way couplet along Haight Street (eastbound) and Maple Street (westbound) through the
city of Poughkeepsie. In between the two streets, NY 376 intersects Main Street (
CR 114). The route ends upon intersecting westbound US 44 and NY 55, at which point the routing of NY 376 becomes an unnumbered town road named Van Wagner Road. ==History==