Route 69 begins at an intersection with Route 104 in the village of
Mexico. The route heads southward, intersecting with local roads. The highway enters a region of rural farmland as it progresses to the southeast. After a while, Route 69 enters Colosse, a hamlet of
Parish. There, it intersects with
U.S. Route 11, which heads northward towards the
Canadian border. Route 69 enters the village of Parish, where it intersects with its lone suffixed route, Route 69A. There it also intersects with several county-maintained roads. In the village of
Parish, Route 69 meets
Interstate 81 at exit 33. Afterwards, the highway leaves the village and re-enters the town, crossing through more farmlands and lakes. Route 69 intersects with more county roads as it heads eastward towards Amboy Center. Route 69 begins curving to the southeast and enters the
Amboy hamlet of Amboy Center, where it intersects with
NY 183. Also present in Amboy Center are two county roads. Route 69 continues southeast, this time towards
Camden, which is in
Oneida County. Route 69 enters Camden, where it becomes concurrent with
NY 13 in the center of the village. Routes 69 and 13 split, and 69 continues out of downtown Camden. Route 69 enters Annsville and Taberg, where it intersects with a couple of county roads. Route 69 continues to the southeast towards
Rome as Rome-Taberg Road. The highway quickly enters Rome and becomes concurrent with
Routes 49 and
46 on the southwestern section of the city. The three routes pass to the south of
Liberty Gardens, an attraction in Rome. The three routes head southward, intersecting with
NY 26, and Route 46 turns off. Routes 49 and 69 head southward and become concurrent with
Route 365. Route 69 turns off after a short distance along NY 365 and continues to the southeast as Rome-Oriskany Road. Route 49 parallels the southeastern moving route to the north away from the city of Rome. Route 69 enters
Oriskany, where it intersects with
NY 291. The highway heads southward, entering
Whitesboro, passing its local fire department memorial park and crossing the
New York State Thruway. Route 69 terminates at an interchange with
NY 5A in
Yorkville. ==History==