As a mother, Ni Guizhen was celebrated for her rigorous yet nurturing approach to raising six children, including the illustrious Soong sisters—Ai-ling, Ching-ling, and May-ling—and three sons, two of whom held prominent roles in the
Republic of China's government. Soong Ai-ling married H. H. Kung in 1914, after working for Sun Yat-sen. H. H. Kung was the richest person in China and later served as the governor of the Bank of China, finance minister and premier of the Republic of China. In June 1915, Soong Ching-ling returned to Shanghai to seek her parents' permission to marry
Sun Yat-sen, the founder of the Republic of China. Ni, as her mother, strongly opposed the idea, pointing out that Sun Yat-sen's son,
Sun Fo, was even older than Ching-ling. Both Ni and Charlie Soong traveled to Japan to dissuade Ching-ling, but despite their efforts, Ni ultimately forgave Sun Yat-sen and accepted the marriage. In 1927, Soong Mei-ling sought her mother's approval to marry Chiang Kai-shek. Initially, Ni objected to the union, but Chiang personally travelled to Japan to appeal to her. As a condition, Ni insisted that Chiang convert to Christianity, to which he agreed. == Death and burial ==