She was selected to contest the
Welsh seat of Llanelli for Labour at the
2005 general election following the imposition of an
all-women shortlist after the retirement of
Denzil Davies. She won the seat with a majority of 7,234 votes and remains the MP there. Griffith made her
maiden speech on 19 May 2005. Griffith was re-elected in 2010 with her majority reduced by 2,533 votes. In October 2010, she became Shadow Minister for Business, Innovation and Skills until October 2011 when she became Shadow Minister for Wales. On 13 September 2015 she became Shadow Secretary of State for Wales. She resigned from this position on 27 June 2016 following a
series of other resignations from Jeremy Corbyn's Shadow Cabinet, but was appointed Shadow Defence Secretary four months later. She supported
Owen Smith in the failed attempt to replace
Jeremy Corbyn in the
2016 Labour leadership election. Griffith is a member of
Labour Friends of Israel. Griffith held her seat at the
2019 general election. She was appointed by
Keir Starmer to serve as
Shadow Secretary of State for Wales on 6 April 2020. On 29 November 2021 she was replaced by
Jo Stevens in a
shadow cabinet reshuffle. She announced her new role of Shadow Minister of State for International Trade on 4 December 2021. She was appointed
Dame Commander of the Order of the British Empire (DBE) in the
2022 Birthday Honours for political and public service. In the
2023 British shadow cabinet reshuffle, she was appointed Shadow Minister in the Cabinet Office. Griffith held her seat at the
2024 general election with 12,751 votes (31.3%); this was a decreased majority of 1,405 compared to the 2019 election. On 9 July 2024, she was appointed a
Parliamentary Under-Secretary of State at the
Wales Office. She left government at the
2025 British cabinet reshuffle. ==Expenses==