The Night Express was an American named train of the Baltimore and Ohio Railroad (B&O) on its route between Detroit, Michigan, and Louisville, Kentucky, with major station stops in Toledo, Ohio, and Cincinnati. The service was numbered Train 57 southbound and Train 58 northbound. The numbers 57/58 operated on the Detroit - Cincinnati line as early as 1921. The service was provided in conjunction with the Pere Marquette Railroad from Detroit to Toledo and with the Louisville and Nashville from Cincinnati to Louisville with connections to New Orleans.