Manuel was drafted ninth overall by
GlobalPort Batang Pier in the
2012 PBA draft. After spending one season at GlobalPort, he was acquired by
Meralco in 2013. On July 12, 2013, prior to the start of the
2013 PBA Governors' Cup he was traded, along with
Carlo Sharma to
Air21 for
Nonoy Baclao and swingman
John Wilson. On March 10, 2014, PBA Commissioner
Chito Salud approved the trade that sent him to
Alaska Aces in exchange for
Aldrech Ramos. With this trade, he reunited with his former coach at Cebuana,
Luigi Trillo. On February 23, 2021, Alaska traded Manuel, along with two draft picks, to
Phoenix Super LPG Fuel Masters for
Brian Heruela and three draft picks. On November 5, 2021, Manuel, along with
Michael Calisaan, was traded to
NorthPort Batang Pier for
Sean Anthony,
Sean Manganti and a 2021 second round draft pick. He never played for NorthPort as he was traded on November 8 to the
San Miguel Beermen for
Arwind Santos. On September 4, 2022, Manuel won his first ever PBA Championship. On November 25, 2024, Manuel was traded to the
Terrafirma Dyip along with
Terrence Romeo for
Andreas Cahilig and
Juami Tiongson. On February 14, 2025, Manuel stated that he will not renew his contract with Terrafirma and intends to play for the
Pangasinan Heatwaves of the
Maharlika Pilipinas Basketball League beginning with the
2025 MPBL season. He will formally join the team on March 1. Before that, he will play for the
Zamboanga Valientes during the Governor Hofer Invitational Basketball Championship in
Zamboanga Sibugay. On December 15, 2025, Manuel returns to the PBA as he signed with the
Converge FiberXers. ==PBA career statistics==