UKS SMS Łódź Karczewska begun her career with Polish second division side
UKS SMS Łódź. At the end of the 2016–17 season, she helped the club to gain promotion to the Polish top flight
Ekstraliga.
Górnik Łęczna In 2019, Karczewska signed with
Ekstraliga side
Gornik Leczna. During her first season with the club, she helped the club to achieve a league and cup double by winning both the
Ekstraliga and
Polish Women's Cup as well as achieving qualification to the
UEFA Women's Champions League.
FC Fleury 91 In June 2021, Karczewska signed with
Division 1 Féminine side
FC Fleury 91. She scored her first goal for the club in a 1–0 win over
ASJ Soyaux-Charente on 25 September 2021. She scored her first hat-trick for the club in a 4-2 league win over
AS Saint-Étienne. In her lone season with the club, she made 24 appearances and netted 10 goals for the club. She ended the season as the club's top scorer and help them to their highest league position to date by finishing 4th in the league.
Tottenham Hotspur In July 2022, Karczewska signed with
Women Super League side
Tottenham Hotspur. On 24 September 2022, she made her club debut in a 4–0 loss against
Arsenal in a league match. She scored her first goal for the club in a
FA WSL Cup win against
Reading on 2 October 2022.
Loan to Bayer Leverkusen On 5 September 2023, Karczewska joined
Bayer Leverkusen on a season-long loan.
AC Milan After a good spell in
Germany, on 28 June 2024 she joined
Serie A club
AC Milan on a permanent deal.
Lazio On 9 July 2025, Karczewska moved to fellow Serie A side
Lazio. == International career ==