The club was founded in 1923 as ''Club Calcistico Giovanile Isola d'Istria
, when the city of Isola was part of Italy. It was known as Ampelea Isola d'Istria
between 1930 and 1946, and played in Serie C between 1937 and 1946. Italian internationals Giuseppe Grezar, Alberto Eliani and Aredio Gimona played with Ampelea in the 1943–44 season. Due to the occupation of Istria and the Trieste territory by the Yugoslav Army, it was forced to change its name to the more proletarian sounding Unione Sportiva Isola
, and finally to NK Izola'' in 1951. The club was dissolved after the
1995–96 Slovenian PrvaLiga season due to financial problems. A successor club was established in 1996 under the name
MNK Izola. ==Honours==