Nzegwu has had a long career in art history, visual art, and curation. A major theme throughout her artwork is the assumptions of Africa and the misinterpretations that exist as a result of colonialism. In the
Journal of Aesthetics and Art Criticism, Nzegwu argues with artist Susan Vogel and Arthur Danto that make claims about African conception of art which Nzegwu heavily critiques as Euro centered. In 2018, she wrote an essay in
Journal of Art Historiography analyzing
oríkì as a Yoruba art form based on
Rowland Abiodun's work. Her claim posited that African art must be evaluated through its original cultural framework, based on where it came from, as opposed to imposed Western structures. She continues the work of decolonizing concepts around gender and African women, using literature. Nzegwu has edited two volumes on Nigerian and Contemporary African art in the 1990s. Nzegwu curated exhibitions across the diaspora in the United States, Canada, and Nigeria. She has had shows at the
Art Gallery of Toronto,
The Power Plant, and
A Space. This documentary explores the life of Nigerian Art and included notable artists such as sculptor
Ben Enwonwu, whose work emphasizes traditional masquerade and African belief systems, and environment-themed paintings by
Ona Brekpaya. ==Teaching and advocacy==