Upon release, "No Se Me Quita" was met with universal acclaim from
music critics. Suzette Fernandez from
Billboard ranked it as one of five essential tracks from
11:11, saying it "will stick on your mind all day" and "its pop sound will make you dance". and
NMEs Nick Levine described Martin's chorus as "brilliant". Brittny Pierre from
Vibe described the collaboration as a "shining moment" for Maluma and labeled the song "a sexy mid-tempo track that will easily get stuck in your head". Also, an author of
¡Hola! entitled them "the kings of rhythm when they come together", and
Los 40's Paloma Diaz Espiñeira named them "the perfect tandem", saying "No Se Me Quita" is "the perfect song to take advantage of the last weeks of summer" and it "adapts perfectly to the musical style of both". Noelia Bertol from
Cadena Dial stated: "The tandem formed by these two artists is synonymous with success." Samy Laurent from
Têtu labeled it "a nice musical piece, which makes you want to wiggle under the sun of the
Indian summer". Writing for
Observatório G, Matheus Henrique Menezes described the track as "a song that promises to be a hit". An author of
Radio Cooperativa called it "[a] joyful and danceable song", and Javier Villacañas from Cadena 100 named it "one of the strong themes on the album".
NRJ staff praised "No Se Me Quita", saying: "The catchy piece with Latino accents makes you want to wiggle on the beach." Thom Jurek from
AllMusic described the song as "a sweet, breezy, infectious tropical summer groover". A writer of
La República appreciated it as "a hit of the summer", and Daniela Llamas from
iHeartRadio ranked it as one of the top 5 songs to enjoy "Acapulco en la azotea". ==Commercial performance==