She began her career at the age of nineteen where she did a lot of children's and educational theatre productions that toured South Africa and the UK. Her first role was in the show
Wild Child Lu. Then she acted in the popular television serials
Rhythm City in 2007 where she played the popular role of 'Tshidi Khuse'. In 2009, she was nominated as the Best Supporting Actress during the 3rd South African Film and Television Awards (SAFTAs). In 2018, she was invited to act in the television series
The River. In the series, she played the role of 'Angelina' and continued to play the role in first and second seasons of the show. Apart from these popular television serials, she has acted in the series
Abomama as 'Mapule' and on
Ambitions as 'Thembi'. She also played supportive roles in the serials
Hard Copy,
Backstage,
Umlilo and
Scandal!. In the remake of original 1977 version of American mini-series
Roots, Nokuthula played a lead role as 'Kunta Kinte's mother'. In the e.tv drama series
Umlilo, she starred the role as 'Dumile', a city girl born and raised in Soweto who is the second wife in a polygamous marriage. ==Filmography==