Nooh Al-Mousa started his career with Al-Fateh where he progressed through the youth ranks. He made his debut for the first team during the 2012–13 season in the match against
Al-Raed. He won the league with Al-Fateh during his first season as a first-team player. Al-Mousa became a regular starter for Al-Fateh during the 2016–17 season where he played 29 matches throughout all competitions. In 2018, as part of a deal between the
Saudi Arabian Football Federation and
La Liga, Al-Mousa joined Spanish club
Real Valladolid on a six-month loan. On April 27, 2018, Al-Mousa signed a 4-year contract with Al-Ahli. On 6 March 2022, Al-Mousa signed a pre-contract with former club Al-Fateh. He joined the club following the expiration of his contract with Al-Ahli. ==International career==