Norpsilocin was found to be a near full
agonist of the
5-HT2A receptor and was found to be more
potent than
psilocin. It also has
affinity for other
serotonin receptors. Norpsilocin has shown psilocin-related
peripheral effects in animals, including decreased
spinal reflexes such as
knee jerk response (opposite effect to psilocin),
antiserotonergic activity (14% of that of psilocin), and
pressor activity (70% of that of psilocin). Surprisingly however, in spite of its serotonin 5-HT2A receptor agonism and psilocin-like effects, norpsilocin failed to induce the
head-twitch response, a behavioral proxy of
psychedelic effects, in animals. ==Research==