There are ten school districts and eleven high schools in Scioto County along with one parochial school as well several private and community schools. The school's athletic affiliation is with the Ohio High School Athletic Association (OHSAA) and the
Southern Ohio Conference (SOC), which has seventeen member schools and is divided into two divisions (SOC I & SOC II) based on the schools' enrollment. Notre Dame is currently in SOC I. Notre Dame participates in baseball, boys' and girls' basketball, boys' and girls' cross country, football, boys' golf, fast-pitch softball, boys' and girls' swimming, boys' and girls' tennis, boys' and girls' track & field, and girls' volleyball.
See also Ohio High School Athletic Conferences and the Southern Ohio Conference.
Ohio High School Athletic Association State Championships • Girls Softball - 2025 ==Notable alumni, coaches, and faculty==