Nuclear receptor coactivator 2

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression. GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1). == Interactions ==

Nuclear receptor coactivator 2 has been shown to interact with: • AR, • ARNT, • BRCA1, • ESR1, • NR3C1, • PPFIA4, • RXRA, • VDR. == References ==