Original In the 1950s, Obetrol was manufactured by Obetrol Pharmaceuticals, in
Brooklyn, New York. The company later became a division of Rexar Pharmacal Corporation, which was also headquartered in Brooklyn. Sometime prior to 1972, Rexar Pharmacal moved its manufacturing facilities, including its Obetrol Pharmaceutical Division, to
Valley Stream, New York. By the 1990s, Obetrol Pharmaceuticals had been wholly absorbed by Rexar Pharmacal and was no longer noted as a division of Rexar. In 1993, Rexar was acquired by Richwood Pharmaceuticals of
Florence, Kentucky, which in 1995 merged with Shire Pharmaceuticals. The 1972 edition of the ''
Physicians' Desk Reference'' lists Obetrol containing (10 mg tablet): • 2.5 mg methamphetamine
saccharate • 2.5 mg methamphetamine
hydrochloride • 2.5 mg
racemic amphetamine
sulfate • 2.5 mg
dextroamphetamine sulfate Obetrol was also available in 20 mg tablets which contained twice the quantity of its ingredients, in the same proportions. The 10 mg tablets were blue, and the 20 mg were orange. Both were inscribed with the letters, "OP". In 1970 the FDA issued an order requiring new drug applications for previously approved amphetamine products. The FDA was critical of combinations of amphetamines and non-amphetamines, but also considered amphetamine and methamphetamine mixtures a combination drug, and required the ingredients to be effective and safe individually and in combination. In September 1973 the FDA withdrew approval for Obetrol under the FDA
Drug Efficacy Study Implementation program. When Richwood acquired Rexar, the drug's name was changed from Obetrol to
Adderall, and the drug was marketed for use in the treatment of
Attention Deficit Disorder (in both children and adults). The old Rexar facility underwent extensive renovations and improvements, and continued to manufacture the drug for several years. During these years, the drug Adderall was identical to the most recent formulation of Obetrol, except that the inscription on the pills was changed to "AD". Sometime after 2000, Shire closed the Rexar manufacturing facility, discontinued immediate-release Adderall and outsourced Adderall XR (extended-release) to a manufacturer in North Carolina. Other companies had begun manufacturing generic versions of Adderall, and the trade name was eventually sold to Barr Pharmaceuticals (acquired by Teva in 2008). There is no drug commercially marketed called Obetrol at this time, nor has there been since Richwood acquired Rexar Pharmacal. ==Abuse==