Obuasi Senior High Technical School is a co-educational second-cycle public high school institution in Obuasi in the Ashanti Region of Ghana. The school is located in between the two towns, Gausu and Koffikrom. It was established by Osagyefo Dr Kwame Nkrumah in 1965 as Government Secondary Technical School, which was an all-boys institution offering science and technical programmes only, the first of its kind in the northern sector of Ghana. In 1990, Obuasi Secondary Technical School was converted into a mixed-sex school to aid the "more girls in science" campaign by the government of Ghana.