Doxycycline can be used in the treatment of ocular rosacea in dosages of 100 mg once or twice a day for a period of 2 to 3 months. Other studies report a good efficacy of 50 mg once a day in less severe cases. A formulation of 40 mg with a delayed release for long-term therapy can also be used. Side effects of treating ocular rosacea with doxycycline include nausea, vomiting, photosensitivity and headache, which may lead to premature discontinuation of treatment. After discontinuation of doxycycline, recurrences may occur within three months; therefore, many studies recommend either slow tapering or treatment with a lower dose over a longer period of time. Low-dose doxycycline (50 mg pe day or less) improves the clinical symptoms of rosacea by its anti-inflammatory effect rather than by its antibiotic effect. == References ==