Odorgonno Senior High School is a Ghanaian based senior secondary school. Its motto is Nobis Nitendum est, which is Latin and means Ours is to Strive. As of 2017, it has 2,671 students and 183 staff, including 53 non-teaching staff. On July 1, 2023, the school's academic prowess was showcased as it emerged victorious in the National Science and Maths Quiz (NSMQ) regional qualifiers, alongside other esteemed institutions like Ashaiman SHS, Labone SHS, and Achimota School. The former Head Prefect/SRC President of Odorgonno Senior High School was Master Humphrey Nyarko. His tenure began after he was declared winner in June 2024. He was assisted by Samuel Yeku(Deputy Headboy). The Girls Prefects were Miss Esther Fosu(Head Girl) and Miss Chantelle Duah(Deputy). The former sports prefect was Kelvin Nyameyie Asante