The total population of
N. oenpelliensis is poorly surveyed, and no study has been made of the rate of its decline. This is partly due to the inaccessibility of the region, a factor that may help the preservation of the species. The conservation status of
Nyctophilopython oenpelliensis is listed by the Northern Territory Government as vulnerable to extinction. This has been evaluated by known threatening factors, such as altered land use and fire regimes, and population inferred from the relative abundance of its prey. This is estimated to be below 10,000, which is inferred from several factors. As a large predator, the species is particularly vulnerable to declines in available prey. These larger mammals are more susceptible to changes in land use and threats such as introduced species. Suitable habitat is also limited in the distribution range of the species. The species is known to be illegally collected for private use, which is likely to impact on some subpopulations. This threat is limited by the inaccessibility of its habitat, the same factor that has restricted study of the species. Variation and decline in subpopulations has not been fully evaluated. It is found within a conservation reserve known as
Kakadu National Park. and has had some limited success. As of July, 2014, the program included six specimens. ==In Aboriginal language and culture==