SR 25 heads westerly from its southern terminus at an interchange with I–75 in rural
Wood County. The highway heads westward, before turning north at an intersection with Cygnet Road (Township Highway 3). The highway heads northeast passing through farmland as a two-lane highway closely paralleling I–75. The route turns due north and becomes a four-lane divided highway, still closely paralleling I–75, before I–75 heads northeasterly. The road has an intersection with
SR 281 and then begins to enter residential properties. The highway enters
Bowling Green at an interchange with
US 6 and passes through commercial properties. SR 25 enters
Perrysburg passing through commercial properties and has an interchange with
Interstate 475 (I–475) and
US 23. At Findlay Street, the highway curves northeasterly and becomes a four-lane undivided highway (West Boundary Street), passing through commercial and residential properties. The road crosses over a set of railroad tracks, before an intersection with
SR 65 (West River Road). SR 65 heads northwest concurrently with SR 25, and the concurrency has an intersection with
US 20 (West Front Street). At the intersection with US 20, SR 65 turns east onto US 20 and SR 25 turns northwest onto US 20 (Maumee–Western Reserve Road). The concurrency heads northwestward as a four-lane undivided highway passing through woodland and crossing over the
Maumee River. SR 25/SR 65 enters
Maumee as Conant Street and has an intersection with
US 24 (Anthony Wayne Trail). At this intersection, SR 25 turns northeasterly, concurrent with US 24. A 2009 traffic report from the
Ohio Department of Transportation (ODOT) showed that the lowest traffic levels were the 5,287 vehicles used the highway daily on the section near its southern terminus, between I–75 and SR 281 in Wood County, while peak traffic volumes were 61,648 vehicles along a section of SR 25 between SR 120 and I–280. ==History==