State Route 53 was an original state highway which stretched from the
Ohio River at
Higginsport to Port Clinton. The route followed that of current
State Route 221 to
Georgetown, then followed the route currently followed by U.S. Route 68 to Kenton, then along its current route into Port Clinton. The route entered Port Clinton and truncated at
State Route 163. Before the Fremont bypass was certified, State Route 53 was routed along the
Sandusky River through
Old Fort into Fremont. In 1929, State Route 53 was routed through the town of
St. Martin, a town it originally bypassed. This reroute was reversed in 1931 and is now
State Route 251. In 1933, State Route 53's southern terminus was moved to Kenton when U.S. Route 68 was certified. In 1946, State Route 53's northern terminus was extended to Catawba Island. It shared a route with State Route 163 for approximately five miles, then split north to the island. This route was formerly the southern portion of
State Route 357. In 1969, State Route 53 was routed along the State Route 2 bypass with an interchange approximately south of its split with State Route 163. ==Major junctions==