The
American Heart Association "supports an omega-6 PUFA intake of at least 5% to 10% of energy in the context of other AHA lifestyle and dietary recommendations. To reduce omega−6 PUFA intakes from their current levels would be more likely to increase than to decrease risk for coronary heart disease." A 2021 review found that omega−6 supplements do not affect the risk of
CVD morbidity and mortality. A 2023 review found that omega−6 polyunsaturated fatty acids are associated with lower risk of high
blood pressure. Omega−6 fatty acids are not associated with
atrial fibrillation. A review and meta-analysis of observational studies by the
World Health Organization (WHO) found that higher intakes of omega−6 are associated with a 9% reduced risk of
all-cause mortality and a 31% increased risk of postmenopausal breast cancer. The increased risk of breast cancer has not been confirmed in randomized controlled trials. A scoping review for Nordic Nutrition Recommendations 2023 found that partial replacement of
saturated fatty acid with omega−6 fatty acid decreases risk of cardiovascular disease and improves the blood lipid profile. ==Dietary sources==