Within Victoria, the passing of the
Country Roads Act 1912 through the
Parliament of Victoria provided for the establishment of the
Country Roads Board (later
VicRoads) and their ability to declare Main Roads, taking responsibility for the management, construction and care of the state's major roads from local municipalities.
Bairnsdale-Bruthen Road was declared a Main Road from
Bairnsdale to
Bruthen on 2 February 1914,
(Tallangatta-) Omeo Road from
Tallangatta through
Mitta Mitta to Granite Flat, and
Tallangatta-Wodonga Road from
Tallangatta to
Wodonga were declared Main Roads on 30 November 1914. The passing of the
Highways and Vehicles Act 1924 provided for the declaration of State Highways, roads two-thirds financed by the state government through the Country Roads Board.
Omeo Road was declared a State Highway on 11 February 1925 - Victoria's first gazetted State Highway The northern end of the highway was truncated back to Tallangatta, with the former alignment running between Wodonga and Tallangatta subsumed into
Murray Valley Highway on its declaration a few years later in September 1932. Omeo Highway was signed as State Route 195 between Tallangatta and Bairnsdale in 1986. The southern end of the highway was truncated back to Omeo, with the former alignment between Omeo and Bairnsdale subsumed into the
Great Alpine Road on its declaration in 1996. With Victoria's conversion to the newer alphanumeric system in the late 1990s, the remainder of the highway was assigned route C543. The passing of the
Road Management Act 2004 through the
Parliament of Victoria granted the responsibility of overall management and development of Victoria's major arterial roads to
VicRoads: VicRoads re-declared the road in 2004 as Omeo Highway (Arterial #6560), from
Tallangatta to
Omeo. ==Major intersections==