El Mariachi is recruited by
CIA officer Sheldon Jeffrey Sands to kill General Emiliano Marquez, a corrupt
Mexican Army officer who has been hired by Mexican drug lord Armando Barillo to assassinate the
President of Mexico and overthrow the government during a period of unrest in
Culiacán (the capital of
Sinaloa) testing the presidency. Many years before, El Mariachi and his wife Carolina confronted Marquez in a shootout and wounded the general; in retaliation, Marquez took the lives of Carolina and their daughter in an ambush. In addition to El Mariachi, Sands persuades former
FBI agent Jorge Ramírez to come out of retirement and kill Barillo, who had murdered his partner Archuleta in the past. Furthermore, AFN operative Ajedrez is assigned by Sands to tail Barillo. While monitoring Barillo's activities, Ramírez meets Billy Chambers, an American fugitive who has been living under the protection of Barillo, but can no longer stomach the horrible tasks he's been forced to carry out for him. Ramírez convinces Chambers he will provide him protection in exchange for getting closer to Barillo by tagging Chambers's pet chihuahua with a hidden microphone, and Chambers agrees to complete the deal by surrendering to U.S. authorities once Barillo has been taken down. Sands's agent, Cucuy, originally hired to keep an eye on El Mariachi, instead turns and tranquilizes El Mariachi and turns him over to Barillo, also offering to reveal the details of Sands's plan. Cucuy, however, is promptly killed by Chambers while El Mariachi escapes from captivity and calls his friends Lorenzo and Fideo to assist him in his mission. While monitoring Barillo's activity outside a hospital, Ramírez notices armed men storming the building and follows suit. He discovers that a group of doctors has been gunned down and Barillo has bled to death as a result of a botched
facial reconstruction but realizes that the corpse on the operating table is a
body double before he is knocked out and kidnapped by the real Barillo and Ajedrez, who reveals herself to be Barillo's daughter. Sands realizes that his mission has been compromised but is too late, as he is captured by Barillo and Ajedrez — who drill out his eyes before sending him out. Despite his blindness, he manages to gun down a hitman tailing him with the aid of a
chicle boy. As
Culiacán celebrates the
Day of the Dead during the President's visit, Marquez and his army storm in and attack the presidential palace. Marquez's troops, however, are met with resistance from not only the President's bodyguards but also the citizens of Culiacán and the Mariachis. Sands had instructed El Mariachi to allow the President to be killed before attacking Marquez, but the Mariachis, concluding that the President is a good man, intervene early and protect him. Marquez enters the presidential palace, only to once again confront El Mariachi, who shoots out his kneecaps before killing him with a headshot. Ramírez, who was released from captivity by Chambers, faces Barillo. After Barillo guns down Chambers, Ramírez and El Mariachi kill the drug lord. Sands manages to shoot the sadistic Ajedrez dead outside the presidential palace. Ultimately, Lorenzo and Fideo walk away with the cash that Barillo was using to pay Marquez and help the president safely escape the attempted
coup. Ramírez says goodbye to Sands and walks away, having avenged his partner's death. El Mariachi then gives his share of the cash to his home village before walking into the sunset. ==Cast==