Highway 76 was first assigned by the
Department of Highways (DHO), predecessor to today's
Ministry of Transportation, on September 16, 1936. It was initially long, connecting Highway 3 with the village of West Lorne to the northwest along an existing
gravel township road. The DHO quickly improved the route, fully paving it by 1938. Several highway routings were altered southwest of
London in late 1957, in anticipation for the construction of Highway 401. On December 5, 1957, Highway 76 was extended northwest to Highway 2 between Wardsville and Strathburn. Highway 401 would open between Tilbury and London as a two lane freeway on October 22, 1963 with an interchange at Highway 76. For nearly two years, traffic utilised the future westbound lanes until the eastbound lanes opened July 20, 1965. Highway 76 remained unchanged for the next 30 years. As part of a series of budget cuts initiated by premier
Mike Harris under his
Common Sense Revolution platform in 1995, numerous highways deemed to no longer be of significance to the provincial network were decommissioned and responsibility for the routes transferred to a lower level of government, a process referred to as downloading. As Highway 76 generally served local traffic as opposed to long-distance movement, it was downloaded to Elgin County and Middlesex County effective April 1, 1997. The two counties each retained the number 76 for the route in their respective county road system. == Major intersections ==