Biology and chemistry •
Base-pair substitution or point mutation, a type of mutation •
Substitution reaction, where a functional group in a chemical compound is replaced by another group •
Substituent, the atom or atoms that replaces those of the reactant • Substitution, a process in which an allele arises and undergoes
fixation Mathematics and computing •
Substitution (algebra), replacing occurrences of some symbol by a given value •
Substitution (logic), a syntactic transformation on strings of symbols of a formal language •
String substitution, a mapping of letters in an alphabet to languages • Substitution of a character in a string, one of the single-character edits used to define the
Levenshtein distance •
Substitution cipher, a method of encryption •
Integration by substitution, a method for finding antiderivatives and integrals
Other uses in science •
Substitution (economics), switching between alternative consumable goods as their relative prices change •
Attribute substitution, a psychological process thought to underlie a number of cognitive biases and perceptual illusions •
Substitution method, a method of measuring the transmission loss of an optical fiber ==Other uses==