OPN1MW2

OPN1MW2 is a duplication of the OPN1MW gene arising from unequal homologous recombination. During this process, one of the X-chromosomes "donates" its OPN1MW gene to the other chromosome, resulting in: • One chromosome without a OPN1MW gene, which carries protanopia • One chromosome with two OPN1MW genes, although only the first gene in the chain (OPN1MW1) will generally be expressed and the second gene OPN1MW2 will remain unexpressed. The only difference between the two genes is their position in the gene cluster. They are equal in that they have the same chances of encoding a certain OPN1MW allele. However, in a given X-chromosome, they may encode different alleles. ==Tetrachromacy==

There are several theories for tetrachromacy in humans, but the most popular theory is related to females carriers of color blindness. Carriers will have one opsin gene (OPN1MW or OPN1LW) with differing alleles thereof on each chromosome, such that the alleles encode proteins with different spectral sensitivities. Both of these alleles are expressed due to x-inactivation (one kind of X chromosome will get expressed in some photoreceptor cells, whereas the other kind of X chromosome will get expressed in the other photoreceptor cells) so a carrier will have 4 distinct cones with different spectral sensitivities, which is one prerequisite of tetrachromacy. This theory cannot be extended to females who have identical alleles in their OPN1MW1 genes, but a different allele in their OPN1MW2 gene, since the latter is never expressed, and if it were co-expressed with OPN1MW1, the two alleles would not be isolated in different photoreceptors. Therefore the OPN1MW2 gene is not considered a likely candidate mechanism for tetrachromacy. ==References==