Mason moved to Murray, Kentucky with her new husband in 1917, and became superintendent of the nursing school there, while maintaining a private medical practice. Both Masons, who were white, treated Black patients in their work, and the couple assisted several promising local Black students to attend college and medical school, including
T. R. M. Howard. Mason, her husband, and her brother-in-law owned and operated the Mason Memorial Hospital in Murray, opened in 1921. The hospital burned down in 1935, but all patients and staff escaped the fire. A new structure resumed the hospital's work in 1937, and survived the death of William Herbert Mason in 1941. Ora Mason was director of nursing and continued to run the hospital's nursing school for a few years, until it stopped admitting new students in 1945. She and other board members sold the hospital in 1947. She retired from medical work in 1957. The nursing education building at
Murray State University was named for her in 1967. Mason was a delegate to the
1924 Republican National Convention, and ran unsuccessfully for an open House seat in 1926, under the name "Mrs. William H. Mason". In 1934 she spoke at a conference on "Citizenship, Government, and the Handicapped Person." She was president of the Murray Woman's Club. She served on the board of regents at Murray State University. == Personal life and death ==