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Organotin chemistry

Organotin chemistry is the scientific study of the synthesis and properties of organotin compounds or stannanes, which are organometallic compounds containing tin–carbon bonds. The first organotin compound was diethyltin diiodide, discovered by Edward Frankland in 1849. The area grew rapidly in the 1900s, especially after the discovery of the Grignard reagents, which are useful for producing Sn–C bonds. The area remains rich with many applications in industry and continuing activity in the research laboratory.

Structure
Organotin compounds are generally classified according to their oxidation states. Tin(IV) compounds are much more common and more useful. Organic derivatives of tin(IV) The tetraorgano derivatives are invariably tetrahedral. Compounds of the type SnRR'RR' have been resolved into individual enantiomers. Organotin halides Organotin chlorides have the formula {{chem2|R_{4−n}SnCl_{n}|}} for values of n up to 3. Bromides, iodides, and fluorides are also known, but are less important. These compounds are known for many R groups. They are always tetrahedral. The tri- and dihalides form adducts with good Lewis bases such as pyridine. The fluorides tend to associate such that dimethyltin difluoride forms sheet-like polymers. Di- and especially tri-organotin halides, e.g. tributyltin chloride, exhibit toxicities approaching that of hydrogen cyanide. Organotin hydrides Organotin hydrides have the formula {{chem2|R_{4−n}SnH_{n}|}} for values of n up to 3. The parent member of this series, stannane (), is an unstable colourless gas. Stability is correlated with the number of organic substituents. Tributyltin hydride is used as a source of hydride radical in some organic reactions. Organotin oxides and hydroxides Organotin oxides and hydroxides are common products from the hydrolysis of organotin halides. Unlike the corresponding derivatives of silicon and germanium, tin oxides and hydroxides often adopt structures with penta- and even hexacoordinated tin centres, especially for the diorgano- and monoorgano derivatives. The group {{chem2|Sn^{IV}\sO\sSn^{IV}|}} is called a stannoxane (which is a tin analogue of ethers), and the group {{chem2|Sn^{IV}\sO\sH}} is also called a stannanol (which is a tin analogue of alcohols). Structurally simplest of the oxides and hydroxides are the triorganotin derivatives. A commercially important triorganotin hydroxide is the acaricide cyhexatin (also called Plictran, tricyclohexyltin hydroxide and tricyclohexylstannanol), (. Such triorganotin hydroxides exist in equilibrium with the distannoxanes: : With only two organic substituents on each Sn centre, the diorganotin oxides and hydroxides are structurally more complex than the triorgano derivatives. The simple tin geminal diols (, the tin analogues of geminal diols ) and monomeric stannanones (, the tin analogues of ketones ) are unknown. Diorganotin oxides () are polymers except when the organic substituents are very bulky, in which case cyclic trimers or, in the case where R is dimers, with and rings. The distannoxanes exist as dimers with the formula wherein the X groups (e.g., chloride –Cl, hydroxide –OH, carboxylate ) can be terminal or bridging (see Table). The hydrolysis of the monoorganotin trihalides has the potential to generate stannanoic acids, . As for the diorganotin oxides/hydroxides, the monoorganotin species form structurally complex because of the occurrence of dehydration/hydration, aggregation. Illustrative is the hydrolysis of butyltin trichloride to give . File:R2SnO-cyclic-trimer-2D.png|Idealized structure of trimeric diorganotin oxide. File:TBu2SnO-cyclic-trimer-from-xtal-1984-Mercury-3D-balls.png|Ball-and-stick model for (. File:R2SnO-cross-linked-network-Harris-and-Sebald-1987-2D.png|Structure of diorganotin oxide, highlighting the extensive intermolecular bonding. Hypercoordinated stannanes Unlike carbon(IV) analogues but somewhat like silicon compounds, tin(IV) can also be coordinated to five and even six atoms instead of the regular four. These hypercoordinated compounds usually have electronegative substituents. Numerous examples of hypercoordinated compounds are provided by the organotin oxides and associated carboxylates and related pseudohalide derivatives. while in the subsequent year a six-coordinated tetraorganotin compound was reported. A crystal structure of room-temperature stable (in argon) all-carbon pentaorganostannate(IV) was reported as the lithium salt with this structure: : In this distorted trigonal bipyramidal structure the carbon to tin bond lengths (2.26 Å apical, 2.17 Å equatorial) are longer than regular C-Sn bonds (2.14 Å) reflecting its hypercoordinated nature. Triorganotin cations Some reactions of triorganotin halides implicate a role for intermediates. Such cations are analogous to carbocations. They have been characterized crystallographically when the organic substituents are large, such as 2,4,6-triisopropylphenyl. Tin radicals (organic derivatives of tin(III)) Tin radicals, with the formula , are called stannyl radicals. They are a type of tetrel radical, and are invoked as intermediates in certain atom-transfer reactions. For example, tributyltin hydride (tris(n-butyl)stannane) serves as a useful source of "hydrogen atoms" because of the stability of the tributytin radical. Organic derivatives of tin(II) Organotin(II) compounds are somewhat rare. Compounds with the empirical formula are somewhat fragile and exist as rings or polymers when R is not bulky. The polymers, called polystannanes, have the formula {{chem2|(SnR2)_{n}|}}. : In principle, compounds of tin(II) might be expected to form a tin analogues of alkenes with a formal double bond between two tin atoms () or between a tin atom and a carbon group atom (e.g. and ). Indeed, compounds with the formula , called distannenes or distannylenes, which are tin analogues of ethylenes , are known for certain organic substituents. The Sn centres in stannenes are trigonal. But, contrary to the C centres in alkenes which are trigonal planar, the Sn centres in stannenes tend to be highly pyramidal. Monomeric compounds with the formula , tin analogues of carbenes are also known in a few cases. One example is , where R is the very bulky . Such species reversibly dimerize to the distannylene upon crystallization: : Stannenes, compounds with tin-carbon double bonds, are exemplified by derivatives of stannabenzene. Stannoles, structural analogs of cyclopentadiene, exhibit little C-Sn double bond character. Organic derivatives of tin(I) Compounds of Sn(I) are rare and only observed with very bulky ligands. One prominent family of cages is accessed by pyrolysis of the 2,6-diethylphenyl-substituted tristannylene [Sn(C6H3-2,6-Et2)2]3, which affords the cubane-type cluster and a prismane. These cages contain Sn(I) and have the formula [Sn(C6H3-2,6-Et2)]n where n = 8, 10 and Et stands for ethyl group. A stannyne contains a tin atom to carbon group atom triple bond (e.g. and ), and a distannyne a triple bond between two tin atoms (). Distannynes only exist for extremely bulky substituents. Unlike alkynes, the core of these distannynes are nonlinear, although they are planar. The Sn-Sn distance is 3.066(1) Å, and the Sn-Sn-C angles are 99.25(14)°. Such compounds are prepared by reduction of bulky aryltin(II) halides. Grey balls: CMagenta (largest) balls: SnStructure of an "prismane", a compound containing Sn(I) (Ar = 2,6-diethylphenyl). == Preparation ==
Preparation
Organotin compounds can be synthesised by numerous methods. Classic is the reaction of a Grignard reagent with tin halides for example tin tetrachloride. An example is provided by the synthesis of tetraethyltin: : The symmetrical tetraorganotin compounds, especially tetraalkyl derivatives, can then be converted to various mixed chlorides by redistribution reactions (also known as the "Kocheshkov comproportionation" in the case of organotin compounds): : : : A related method involves redistribution of tin halides with organoaluminium compounds. : The organotin hydrides are generated by reduction of the mixed alkyl chlorides. For example, treatment of dibutyltin dichloride with lithium aluminium hydride gives the dibutyltin dihydride, a colourless distillable oil: : The Wurtz-like coupling of alkyl sodium compounds with tin halides yields tetraorganotin compounds. Hydrostannylation involves the metal-catalyzed addition of tin hydrides across unsaturated substrates. Alternatively, stannides attack organic electrophiles to give organostannanes, e.g.: :LiSnMe3 + CCl4 → C(SnMe3)4 + LiCl. == Reactions ==
Reactions
Important reactions, discussed above, usually combine organotin halides and pseudohalides with nucleophiles. All-alkyl organotin compounds generally do not hydrolyze except in concentrated acid; the major exception being tin acetylides. An organostannane addition is nucleophilic addition of an allyl-, allenyl-, or propargylstannanes to aldehydes and imines, whereas hydrostannylation conveniently reduces only unpolarized multiple bonds. Organotin hydrides are unstable to strong base, disproportionating to hydrogen gas and distannanes. The latter equilibrate with the corresponding radicals only in the continued presence of base, or if strongly sterically hindered. Conversely, mineral acids cleave distannanes to the organotin halide and more hydrogen gas. In "pure" organic synthesis, organotin reactions are unpopular, because organotin wastes are difficult to separate from the desired product and toxic even in extremely low concentrations. Strategies to remove the wastes include forming insoluble iodides or fluorides or covalently affixing the tin compounds to a solid polymer surface. Nevertheless, the Stille reaction is considered is a key coupling technique. In the Stille reaction, sp2-hybridized organic halides (e.g. vinyl chloride ) catalyzed by palladium: :{{chem2|R^{1}\sX + R^{2}\sSn(R^{3})3}} {{chem2|R^{1}\sR^{2} + X\sSn(R^{3})3}} Organotin compounds are also used extensively in radical chemistry (e.g. radical cyclizations, Barton–McCombie deoxygenation, Barton decarboxylation, etc.). ==Applications and toxicity==
Applications and toxicity
Image:Tetrabutyltin.svg|Tetrabutyltin colorless oil, precursor to the other butyl-tin compounds Image:Tributyltin oxide.png|Tributyltin oxide, a colorless to pale yellow liquid used in wood preservation Image:Fentin acetate.svg|Triphenyltin acetate, an off-white crystalline solid, used as an insecticide and a fungicide Image:Triphenyltin chloride.png|Triphenyltin chloride, a highly toxic white solid, used as a biocide Image:Trimethyltin chloride.png|Trimethyltin chloride, a toxic white solid, once used as a biocide Image:Triphenyltin hydroxide.svg|Triphenyltin hydroxide, an off-white powder, used as a fungicide Image:Azocyclotin.svg|Azocyclotin, a white solid, used as a long-acting acaricide for control of spider mites on plants Image:Cyhexatin.svg|Cyhexatin, a white solid, used as an acaricide and miticide Image:Hexamethylditin.svg|Hexamethylditin used as an intermediate in chemical synthesis Image:Tetraethyltin.svg|Tetraethyltin, boiling point 63–65° at 12 mmHg is a catalyst. The "Et" symbol stands for ethyl group. Organotin compounds, mainly diorganotin dithiolates (formula ), heat-stabilize polyvinyl chloride during production. The plastic dehydrochlorinates and exhibits undesirable brittleness if heated unstabilized. The stabilizers work by reducing allylic chlorides to allylic mercaptans and absorbing catalytic hydrogen chloride. This application consumes about 20,000 tons of tin each year. over off-target toxicity and bioaccumulation (some reports describe biological effects to marine life at a concentration of 1 nanogram per liter) led to a worldwide ban by the International Maritime Organization. As anti-fouling compounds, organotin compounds have been replaced by dichlorooctylisothiazolinone. Monoorgano, diorgano- and tetraorganotin compounds are far less dangerous than triorganotin compounds, The ototoxicity of organotin compounds in humans is not conclusively known, but the United States Occupational Safety and Health Administration and National Institute for Occupational Safety and Health include them in an advisory list of metal-based ototoxicants alongside lead and mercury. In guinea pigs, trimethyltin chloride was acutely and persistently ototoxic at 2 mg/kg, but in rats no such effect occurred. == See also ==
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