The Ostioneros de Guaymas were established in 2008. They joined the
Circuito de Baloncesto de la Costa del Pacífico (CIBACOPA), becoming the third team from Guaymas to play in the league after the Marineros and the Bucaneros. The Ostioneros de Guaymas played their debut season in 2009 and finished third in the North Zone with a 20–20 record. The team was eliminated in the quarterfinals by the
Rayos de Hermosillo. Two Ostioneros players, Larry Satchell and Jorge Rochín, were named to the All-Star Game. They won their first playoff series in team history by defeating the
Frayles de Guasave in seven games. Ostioneros
forward Jerome Habel led the team with 19 points and 11 rebounds in their 94–61
blowout victory in game 7. In 2012, Guaymas improved to 27–11 and finished second to the Rayos de Hermosillo in wins. The Ostioneros defeated the
Fuerza Guinda de Nogales in five games in the quarterfinals before beating the
Tijuana Zonkeys in a seven-game semi-final series to qualify for their its first CIBACOPA finals. The Ostioneros finished second in the standings once again in 2013 with a 23–9 record. However, they were swept 4–0 in the opening round of the playoffs by the Mineros de Cananea. Guaymas hired Andrés "Veneno" Contreras as their head coach ahead of the 2015 season. They also signed
Orien Greene. The Ostioneros finished the year with a league-best 28–10 record and second in the general table, behind only the Náuticos de Mazatlán. Guaymas beat the
Caballeros de Culiacán, 4–1, in the quarterfinals. However, they were defeated by the
Fuerza Guinda de Nogales in the semi-finals, losing the decisive game 7 by a score of 85–74. Ahead of the 2016 season, the Ostioneros signed
Devin Green. They defeated the
Vaqueros de Agua Prieta in the first round of the playoffs before losing to the Náuticos de Mazatlán, 4–1, in the semi-finals. Guaymas then went 19–19 the following year for a sixth-place finish. They beat the Tijuana Zonkeys in the quarterfinals but were once again eliminated in the semi-finals, losing in five games to the Rayos de Hermosillo. By this time, a rivalry had developed between Guaymas and Hermosillo. The team failed to reach the playoffs, losing the eight seed to the
Halcones de Ciudad Obregón on a tiebreaker. Guaymas announced a new head coach, Mike Corona, ahead of the
2019 season. The team returned to the playoffs, but were eliminated by the Rayos de Hermosillo in the first round. Guaymas played only two games, going 1–1, before the season was interrupted due to the
COVID-19 pandemic. The 2021 season was subsequently cancelled as well. In February 2022, Guaymas hired longtime
NBA assistant
John Welch as their new head coach ahead of their return to play. The Ostioneros went 19–15 that season, finishing second in the general table. However, they were eliminated in the first round of the playoffs by the
Venados de Mazatlán, who came back from a 3–0 series deficit to beat Guaymas 93–85 in game 7. For the 2023 season, the Ostioneros hired Spanish coach
Pedro Carrillo to take the reins. They also signed American import
Markel Crawford. They opened the season with a 141–140 victory over the Rayos de Hermosillo in six overtimes, setting a new record for the longest game in league history. The team finished seventh in the general table after compiling a 12–22 record. They were eliminated in the quarterfinals once again, losing in six games to the
Astros de Jalisco. Ahead of the
2024 season, the Ostioneros hired Ben Sanders as their head coach. Crawford served as
team captain and earned All-Star honors, along with teammate
Jahvon Blair. Guaymas finished seventh in the general table after compiling a 15–21 record. They were eliminated in the first round of the playoffs by the Tijuana Zonkeys. ==Home arena==