•
Amos Otis (born 1947), American retired Major League Baseball player •
Bill Otis (1889–1990), American Major League Baseball player •
Charles Otis (disambiguation) •
Elisha Otis (1811–1861), American inventor and industrialist, inventor of an elevator safety device and founder of Otis Elevator Company •
Eliza Ann Otis (1833–1904), American poet, journalist, and philanthropist, co-founder, publisher and associate editor of the
Los Angeles Times newspaper •
Elwell Stephen Otis (1838–1909), American general who served in the Civil War, Spanish-American War and Philippine-American War •
George Demont Otis (1879–1962), American landscape painter •
George L. Otis (1829–1882), American lawyer and politician •
Glenn K. Otis (1929–2013), US Army four-star general •
Harrison Gray Otis (politician) (1765–1848), American politician and senator from Massachusetts •
Harrison Gray Otis (publisher) (1837–1917), a publisher of the
Los Angeles Times •
James Otis (disambiguation) •
John Otis (Maine politician) (1801–1856), U.S. Representative from Maine •
John G. Otis (1838–1916), U.S. Representative from Kansas •
John Lord Otis (1827-1894), American Civil War officer and Massachusetts state senator and state representative •
Johnny Otis (1921–2012), American singer, musician, composer, bandleader, record producer and talent scout •
Mercy Otis Warren (1728–1814), née Otis, American activist poet, playwright and pamphleteer during the American Revolution •
Samuel Allyne Otis (1740–1814), American politician and first Secretary of the United States Senate •
Samuel Shackford Otis (1891–1974), American architect •
Shuggie Otis (born 1953), American songwriter, recording artist and multi-instrumentalist •
Todd Otis (born 1945), American politician •
William Otis (1813–1839), American inventor of the steam shovel ==See also==